Novel Mutation in Hereditary Spastic Paraplegia with Thin Corpus Callosum.

Dear Sir, Mutations in SPG11 are the major causes of autosomal recessive (AR) hereditary spastic paraplegia with thin corpus callosum (HSP-TCC). Lancet Neurol 2019;18:1136-46. 2 Patel S, Sethi PK, Anand I, Batra A, Gupta P. Hereditary spastic paraplegia with a thin corpus callosum due to SPG11 mutation. His brain magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) revealed a TCC accompanied by periventricular white matter abnormal changes. [Extracted from the article]