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Myocarditis after RNA-based vaccines for coronavirus.
- Source :
-
International Journal of Cardiology . Apr2022, Vol. 353, p131-134. 4p. - Publication Year :
- 2022
-
Abstract
- The incidence of myocarditis after RNA-based vaccines for coronavirus has gained social and medical interest. We performed an intention-to-treat meta-analysis, following the PRISMA statement. After a systematic search, without language restriction, 9 publications were selected. Two were excluded (one was only in subjects with age 12–17 and other might had included subjects from a larger publication). We followed the PRISMA guidelines for abstracting data and assessing data quality and validity. Data was verified by 2 investigators. We analyzed 17,704,413 subjects, from 7 studies, that included 627 cases of confirmed myocarditis). The incidence of myocarditis was 0.0035% (95% CI 0.0034–0.0035). Mean incidence rate was 10.69 per 100.000 persons-year. Cases reported from Israel represented 45.14% from total (283 out of the 627). Only 1 case of fatal myocarditis or death was reported. There was significant heterogeneity between results. The meta-regression analysis excluded mean age, region, number of cases or number of people included as sources of heterogeneity. No small-study effect was observed (p = 0.19). Myocarditis incidence after RNA vaccines is very rare (0.0035%) and has a very favorable clinical course. [Display omitted] • I ncidence of myocarditis after RNA-based vaccines for coronavirus has gained social and medical interest. • We performed a meta-analysis with 17,704,413 subjects that included 627 confirmed myocarditis. • The incidence of myocarditis was 0.0035% (95% CI 0.0034–0.0035). • Mean incidence rate was 10.69 per 100.000 persons-year. • Only 1 case of fatal myocarditis or death was reported. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COVID-19 vaccines
*MYOCARDITIS
*CORONAVIRUS diseases
*DEATH rate
*DATA quality
Subjects
Details
- Language :
- English
- ISSN :
- 01675273
- Volume :
- 353
- Database :
- Academic Search Index
- Journal :
- International Journal of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 155751797
- Full Text :
- https://doi.org/10.1016/j.ijcard.2022.01.037