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Conjugation of RNA via 2′-OH acylation: Mechanisms determining nucleotide reactivity.
- Source :
-
Chemical Communications . 3/18/2022, Vol. 58 Issue 22, p3693-3696. 4p. - Publication Year :
- 2022
-
Abstract
- The acylation reactivity of RNA 2′-OH groups has proven broadly useful for labeling and mapping RNA. Here we perform kinetics studies to test the mechanisms governing this reaction, and we find strong steric and inductive effects modulating reactivity. The results shed light on new strategies for improved conjugation and mapping. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RNA
*INDUCTIVE effect
*ACYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 155868850
- Full Text :
- https://doi.org/10.1039/d2cc00660j