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Stable high-oxidation-state complex in situ Mn(V)–Mn(III) transition to achieve highly efficient cervical cancer therapy.
- Source :
-
Chemical Communications . 3/21/2022, Vol. 58 Issue 23, p3759-3762. 4p. - Publication Year :
- 2022
-
Abstract
- Designing metal complexes to target the vulnerable redox balance in cancer cells is a promising strategy to realize successful cancer therapy. The synthesized stable nitridomanganese(V) complex MnV(N) (salen) not only reacts with GSH to achieve in situ Mn(V)–Mn(III) transformation to down-regulate the antioxidant system, but also catalyzes H2O2 to higher oxidation capacity ROS to up-regulate the intracellular oxidative level, finally resulting in cancer cell death. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CERVICAL cancer
*CANCER treatment
*CANCER cells
*CELL death
*METAL complexes
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 155868866
- Full Text :
- https://doi.org/10.1039/d1cc06819a