过渡金属掺杂磁性纳米粒子在生物医学领域中的研究进展.

Magnetic nanomaterials （MNPs） have been extensively studied and applied in the past half century due to their unique properties including coordinated magnetic properties, non-invasive, easy manipulation, and good biocompatibility. However, the complex magnetic behavior of MNPs is influenced by a variety of factors, including particle size, composition, shape, and core-shell structure. Therefore, the main parameters of MNPs are needed to coordinate accordingly for specific applications to improve their effectiveness. Among them, doping of divalent transition metal ions is a crucial parameter affecting various magnetic properties of MNPs such as magnetic moment （μ）, saturation magnetization strength （Ms ）, coercivity（Hc ）, magnetic crystal anisotropy（K）and relaxation time（τN and τB ）. Therefore, this review focuses on the mechanism of precisely regulating the magnetic properties of magnetic nanomaterials by doping them with transition metal ions, and introduces the potential mechanisms and some recent advances of MNPs doped with transition metal ions for bioimaging detection（magnetic resonance imaging and magnetic particle imaging）, drug precision delivery and tumor therapy, and biosensing. Finally, we summarize some challenges and future trends of MNPs. [ABSTRACT FROM AUTHOR]