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Merging C–C σ-bond activation of cyclobutanones with CO2 fixation via Ni-catalysis.
- Source :
-
Chemical Communications . 3/28/2022, Vol. 58 Issue 25, p4071-4074. 4p. - Publication Year :
- 2022
-
Abstract
- A carboxylative Ni-catalyzed tandem C–C σ-bond activation of cyclobutanones followed by CO2-electrophilic trapping is documented as a direct route to synthetically valuable 3-indanone-1-acetic acids. The protocol shows an adequate functional group tolerance and useful chemical outcomes (yield up to 76%) when AlCl3 is adopted as an additive. Manipulations of the targeted cyclic scaffolds and a mechanistic proposal based on experimental evidence complete the investigation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CYCLOBUTANONES
*FUNCTIONAL groups
*ADHESION
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 25
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 155933270
- Full Text :
- https://doi.org/10.1039/d2cc00149g