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Note on DNA Analysis and Redesigning Using Markov Chain.

Authors :
Zakarczemny, Maciej
Zajęcka, Małgorzata
Source :
Genes. Mar2022, Vol. 13 Issue 3, p554-N.PAG. 15p.
Publication Year :
2022

Abstract

The paper contains a discussion on mathematical modifying and redesigning DNA with the use of Markov chains. We give a simple mathematical technique for overwriting missing parts of DNA. With a certain probability (without even knowing the function of the missing codon) we can find a synonymous codon, so that there is no frequency change in amino acid sequences of proteins. We use Markov Chain to analyze the dependencies in DNA sequence of the human gene Alpha 1,3-Galactosyltransfe rase 2. We include a theoretical introduction which facilitates the understanding of the paper for non-mathematicians, especially for biologists not familiar with the theory of Markov chains. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20734425
Volume :
13
Issue :
3
Database :
Academic Search Index
Journal :
Genes
Publication Type :
Academic Journal
Accession number :
156019281
Full Text :
https://doi.org/10.3390/genes13030554