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Nitrative bicyclization of 1,7-diynes for accessing skeletally diverse tricyclic pyrroles.
- Source :
-
Chemical Communications . 4/7/2022, Vol. 58 Issue 27, p4376-4379. 4p. - Publication Year :
- 2022
-
Abstract
- A novel metal-free nitrative bicyclization of 1,7-diynes with tBuONO in the presence of H2O is reported, producing three types of skeletally diverse tricyclic pyrroles, namely pyrrolo[3,4-c]quinolines, chromeno[3,4-c]pyrroles and benzo[e]isoindoles, with moderate to good yields by simply tuning the linkers of the 1,7-diynes. This domino protocol demonstrates remarkable compatibility regarding 1,7-diynes with different linkers, such as nitrogen and oxygen atoms and a hydroxymethyl group, and tBuONO plays dual roles as a nitro precursor as well as a nitrogen atom source. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PYRROLES
*QUINOLINE
*ISOINDOLE
*HYDROXYMETHYL compounds
*POLYPYRROLE
*ATOMS
*NITROGEN
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 27
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 156053547
- Full Text :
- https://doi.org/10.1039/d2cc00206j