Determining the nonlinearity in an acoustic wave equation.

We consider an undetermined coefficient inverse problem for a nonlinear partial differential equation describing high‐intensity ultrasound propagation as widely used in medical imaging and therapy. The usual nonlinear term in the standard model using the Westervelt equation in pressure formulation is of the form ppt. However, this should be considered as a low‐order approximation to a more complex physical model where higher order terms will be required. Here we assume a more general case where the form taken is f(p) pt and f is unknown and must be recovered from data measurements. Corresponding to the typical measurement setup, the overposed data consist of time trace observations of the acoustic pressure at a single point or on a one‐dimensional set Σ representing the receiving transducer array at a fixed time. Additionally to an analysis of well‐posedness of the resulting pde, we show injectivity of the linearized forward map from f to the overposed data and use this as motivation for several iterative schemes to recover f. Numerical simulations will also be shown to illustrate the efficiency of the methods. [ABSTRACT FROM AUTHOR]