慢阻肺患者肺功能与HRCT支气管壁厚度的相关性.

Objective　To investigate the correlation of pulmonary function indexes and bronchial wall thickness measured as computed with high resolution computed tomography in patients with chronic obstructive pulmonary diseases. Methods　Eighty COPD patients were assigned to four groups based on the new COPD Global Initiative Classification, meanwhile，fifty normal people with physical examination in the hospital were selected as controls simultaneously. All subjects underwent chest HRCT scanning to measure the bronchial wall thickness at the bilateral apical bronchial opening，and the correlation between the bronchial wall thickness and lung function was studied. Results　Bronbronchial wall thickness was significantly increased in COPD patients compared with normal population，and the difference was statistically significant （ P < 0.05）. From the mild group to the very severe group， the bilateral bronchial wall thickness gradually increased，FEV1，FVC，FEV1/FVC gradually decreased，with statistically significant differences （ P < 0.05） . Correlation analysis： bilateral bronchial wall thickness was significantly inversely associated with each index of lung function （ P < 0.05）. Conclusions　HRCT can be used to measure bronchial wall thickness and evaluate the degree of bronchial wall remodeling in COPD patients. With the deepening of the disease grade，the thickness of the bronchial wall of COPD patients gradually increased. There is a significant correlation between lung function indexes and bronchial wall thickness，that is，the thickening of bronchial wall，the decline of lung function indexes and the deterioration of lung function. HRCT measurement of bronchial wall thickness in COPD patients has clinical significance for the evaluation of the severity of the disease. [ABSTRACT FROM AUTHOR]