GnRH类似物对子宫肌瘤大鼠模型血液黏度、子宫系数和炎性细胞浸润的影响.

Objective: To investigate the effects of Gonadotropin releasing hormone (GnRH) analogues on blood viscosity, uterine coefficient and inflammatory cell infiltration in rat models of uterine fibroids. Methods: Rat models of uterine fibroids (n=36) were equally randomly divided into three groups-model group, mifepristone group and GnRH analogue group. The three groups were given intraperitoneal injection of 0.15 mL of normal saline, 2 mg/kg of mifepristone, 2 mg/kg GnRH analogue, once a week for 8 weeks. Results: The values of whole blood specific viscosity, follicle stimulating hormone (FSH) and luteinizing hormone (LH) in the 4th and 8th weeks of treatment in the mifepristone group and GnRH analog group were lower than those of the model group (P<0.05), the GnRH analog group were lower than mifepristone group (P<0.05). Uterine coefficient, uterine interleukin (IL)-10 and tumor necrosis factor (TNF)-α expression levels in the mifepristone group and GnRH analog group at the 8th week of treatment were lower than those in the model group (P<0.05), GnRH analog The group were lower than the mifepristone group (P<0.05). The endometrial thickness, gland-to- interstitial area ratio, gland area and gland cavity area of the mifepristone group and the GnRH analog group were higher than the model group at the 8th week of treatment (P<0.05), and the GnRH analog group were higher than that in the GnRH analog group Mifepristone group (P<0.05). The relative expression levels of Wnt5b and β-catenin protein in the uterine tissue of the mifepristone group and the GnRH analog group were lower than the model group at the 8th week of treatment (P<0.05), and the GnRH analog group were lower than the mifepristone group (P< 0.05). Conclusion: The application of GnRH analogues in rat models of uterine fibroids can reduce blood viscosity, inhibit the secretion of serum sex hormones, increase uterine coefficient, and inhibit the expression of Wnt5b and β-catenin proteins, thereby improving morphology of the endometrium uterine fibroids and the infiltration state of inflammatory cells in rats. [ABSTRACT FROM AUTHOR]