Type II cGMP-dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells.

PKG II, cGMP-dependent protein kinase type II; EGF, epidermal growth factor; Ad-LacZ, adenoviral vector containing the -galactosidase gene; Ad-PKG II, adenoviral vector containing the PKG II gene; cGMP, cyclic guanosine monophosphate. PKG II, cGMP-dependent protein kinase type II; Ad-LacZ, adenoviral vector containing the -galactosidase gene; Ad-PKG II, adenoviral vector containing the PKG II gene; 8-pCPT-cGMP, 8-(4-chlorophenylthio)-cGMP; cGMP, cyclic guanosine monophosphate; EGF, epidermal growth factor. [Extracted from the article]