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Secondary Metabolites, including a New 5,6-Dihydropyran-2-One, Produced by the Fungus Diplodia corticola. Aphicidal Activity of the Main Metabolite, Sphaeropsidin A.

Authors :
Salvatore, Maria Michela
Di Lelio, Ilaria
DellaGreca, Marina
Nicoletti, Rosario
Salvatore, Francesco
Russo, Elia
Volpe, Gennaro
Becchimanzi, Andrea
Mahamedi, Alla Eddine
Berraf-Tebbal, Akila
Andolfi, Anna
Source :
Molecules. Apr2022, Vol. 27 Issue 7, p2327-2327. 9p.
Publication Year :
2022

Abstract

An undescribed 5,6-dihydropyran-2-one, namely diplopyrone C, was isolated and characterized from the cultures of an isolate of the fungus Diplodia corticola recovered from Quercus suber in Algeria. The structure and relative stereostructure of (5S,6S,7Z,9S,10S)-5-hydroxy-6-(2-(3-methyloxiran-2-yl)vinyl)-5,6-dihydro-2H-pyran-2-one were assigned essentially based on NMR and MS data. Furthermore, ten known compounds were isolated and identified in the same cultures. The most abundant product, the tetracyclic pimarane diterpene sphaeropsidin A, was tested for insecticidal effects against the model sucking aphid, Acyrthosiphon pisum. Results showed a toxic dose-dependent oral activity of sphaeropsidin A, with an LC50 of 9.64 mM. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14203049
Volume :
27
Issue :
7
Database :
Academic Search Index
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
156324680
Full Text :
https://doi.org/10.3390/molecules27072327