核苷酸结合寡聚化结构域样受体蛋白 3 炎性小体 在肝脏疾病中的作用机制.

Inflammasomes play an important role in the innate immunity of the liver; however, the excessive activation of inflammasomes can lead to liver inflammation and injury. The mechanism of nucleotide - binding oligomerization domain - like receptor protein 3 ( NLRP3) inflammasome - mediated liver injury has been extensively studied. Related studies have shown that the development of various liver diseases may be associated with the excessive activation of inflammasomes, especially NLRP3 inflammasome. This article reviews inflammasomes, the activation mechanism of NLRP3 inflammasome, and the role of NLRP3 inflammasome in different liver diseases, so as to provide a reference for the treatment targets of liver diseases from the perspective of NLRP3 inflammasome. [ABSTRACT FROM AUTHOR]