儿童幽门螺杆菌感染情况及其与缺铁性贫血的相关性.

Objectives To investigate the infection of H.pylori in 528 children with epigastric pain in Dali Bai Autonomous Prefecture People’ s Hospital, to study the correlation between infection and iron deficiency anemia (IDA) and to provide evidence for the diagnosis and treatment of H.pylori infection and IDA in children. Method A total of 528 children aged 3 to 13 who received 13C-UBT due to upper abdominal pain in the outpatient department of Dali Bai Autonomous Prefecture People’s Hospital from January 2019 to December 2020 were selected, and the gender and ethnicity of the detected children were analyzed by questionnaire. There were 119 H.pylori positive children listed as the observation group, and 409 H.pylori negative children listed as the control group. Hemoglobin (Hb), mean red blood cell Volume (MCV), serum iron (SI), total iron binding capacity (TIBC) and serum ferritin (SF) were tested to determine the occurrence of IDA, and the correlation between H.pylori infection and IDA was analyzed. Results The total infection rate of H.pylori in 528 children was 22.53%, and the positive rates of H.pylori in male and female children were 22.88% and 22.22%, respectively. There was no significant difference in the positive rate of H.pylori in male and female children (χ2 = 0.08, P > 0.05). The positive rates of H.pylori infection in Han, Bai, Tibetan and other minority children were 17.95%, 20.69%, 64.29% and 26.92%, respectively. The positive rate of H.pylori infection was significantly different (χ2 = 273.659, P < 0.01). The levels of Hb, MCV, SI and SF in the observation group were significantly lower than those in the control group, and the level of TIBC was significantly higher than that in the control group, with statistical significance (P < 0.05). Conclusion H.pylori infection rate was not related to gender, and there were obvious ethnic clusters. H.pylori infection is associated with IDA in children and may be a risk factor for IDA. Therefore, routine H pylori monitoring and anti-H.pylori treatment should be included in the clinical treatment of IDA to obtain better clinical outcome. [ABSTRACT FROM AUTHOR]