A forodesine-based regimen as a therapeutic option for PTCL-NOS with Central nervous system involvement.

Therefore, tumor cell invasion may have damaged the BBB, resulting in the effective transfer of forodesine from the circulating blood to the CNS. No leukemic cell infiltration was proven at tissue biopsy from palate ulcers, and the number of tumor cells in peripheral blood remained about the same. Although the invasion of tumor cells into the central nervous system (CNS) occurs in some cases [[3]], no standard strategy to prevent or control CNS involvement has been established. Furthermore, the patient presented with intestinal occlusion and colon ulcers, and biopsy specimens from the intestinal lesions showed the invasion of T-lineage tumor cells. [Extracted from the article]