Effect of vitamin D on arterial stiffness in type 2 diabetes patients with intermediate chronic kidney disease.

Purpose: To evaluate the association between serum 25-hydroxy vitamin D level and arterial stiffness in type 2 diabetes patients with intermediate chronic kidney disease (CKD). Methods: The serum 25-hydroxy vitamin D level and various parameters of vascular functions were assessed in type 2 diabetes patients with intermediate CKD (stages 3a and 3b). The carotid-femoral pulse wave velocity (cfPWV) among vitamin D-deficient, -insufficient, and normal patients was compared. Results: One hundred and twenty-one patients were included. The cfPWV in the vitamin D-deficient group (1190.32 ± 256.95 cm/s) was significantly higher (p < 0.05) than that in the vitamin D-insufficient (1053.74 ± 138.96 cm/s) and normal (1038.45 ± 171.08 cm/s) groups. Similarly, the aortic augmentation pressure (13.29 ± 5.18 mm Hg) in the vitamin D-deficient group was significantly higher (p < 0.05) than that in the vitamin D-insufficient (10.01 ± 5.12 mm Hg) and normal groups (9.27 ± 4.97 mm Hg). Furthermore, the augmentation index was 24.66 ± 8.84% in the vitamin D-deficient (p < 0.05) as compared to 20.11 ± 8.12% in the vitamin D-insufficient group and 20.36 ± 6.14% in the normal group. Other vascular parameters were not significantly different among the groups. Conclusion: Different parameters of arterial stiffness, such as cfPWV, aortic augmentation pressure, and augmentation index, were significantly higher in the vitamin D-deficient group as compared to those in the vitamin D-insufficient and normal groups among type 2 diabetes patients with intermediate CKD. [ABSTRACT FROM AUTHOR]