广泛性焦虑障碍患者人格特征与免疫功能、甲状腺激素 和神经内分泌激素的相关性分析.

Objective: To explore the correlation between personality characteristics and immune function, thyroid hormone and neuroendocrine hormone in patients with generalized anxiety disorder (GAD). Methods: 80 patients with GAD who were treated in Department of Psychology, Northern Theater Air Force Hospital from January 2019 to December 2020 were selected as the study group, and 80 healthy volunteers who underwent physical examination of the Northern Theater Air Force Hospital in the same period served as the control group. The simple Eysenck Personality Questionnaire (EPQ-RSC) was used to evaluate the personality characteristics of the subjects. The results of EPQ-RSC score, the proportions of CD3+, CD4+ and natural killer (NK) cells in blood, serum interleukin (IL)-2 andIL-6, triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), norepinephrine (NE), adrenocorticotropin (ACTH) and cortisol (CS) levels were compared between the two groups, and their correlation were analyzed. Results: The psychoticism(P), neuroticism(N) and EPQ-RSC total scores in the study group were significantly higher than those in the control group (P<0.05), CD3+, CD4+ and NK in the study group were significantly lower than those in the control group, and IL-2and IL-6 were significantly higher than those in the control group (P<0.05). FT3 and FT4 in the study group were significantly lower than those in the control group(P<0.05). CS in the study group was significantly lower than that in the control group, NE and ACTH were significantly higher than those in the control group (P<0.05). Pearson correlation analysis showed that N, P and EPQ-RSC total scores were negatively correlated with CD3+, CD4+, NK, FT3, FT4 and CS of GAD(P<0.05), and positively correlated with IL-2, IL-6, NE and ACTH(P<0.05). Conclusion: Patients with GAD have impaired immune function and abnormal levels of neuroendocrine hormone and thyroid hormone, which are related to P and N propensity personality characteristics of patients. [ABSTRACT FROM AUTHOR]