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Apelin signalling: a promising pathway from cloning to pharmacology
- Source :
-
Cellular Signalling . Apr2005, Vol. 17 Issue 4, p415-426. 12p. - Publication Year :
- 2005
-
Abstract
- Abstract: The discovery of new signalling pathways is always followed by the development of pharmacological agents as drugs that can be used in the treatment of diseases resulting from a dysfunction of the signalling pathway in question. Apelin signalling plays a role in the central and peripheral regulation of the cardiovascular system, in water and food intake, and possibly in immune function. Up-regulation of ligand and receptor is also associated with pathophysiological states such as cardiac dysfunction and neovascularisation. Finally, the apelin receptor is a coreceptor for the entry of several HIV-1 and SIV strains. In view of these features, the apelin receptor constitutes a very interesting target for the design of new drugs for treating the prime causes of human mortality. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 08986568
- Volume :
- 17
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Cellular Signalling
- Publication Type :
- Academic Journal
- Accession number :
- 15647526
- Full Text :
- https://doi.org/10.1016/j.cellsig.2004.09.018