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Fenton-like reaction and glutathione depletion by chiral manganese dioxide nanoparticles for enhanced chemodynamic therapy and chemotherapy.
- Source :
-
Journal of Colloid & Interface Science . Jun2022, Vol. 616, p369-378. 10p. - Publication Year :
- 2022
-
Abstract
- [Display omitted] Chirality-based nanomaterials, especially semiconductors nanoparticles (NPs), are the emerging research in biomedicine field. Herein, chiral manganese dioxide (L/D-MnO 2) NPs were synthesized by using threonine molecules as chiral ligands. Then cisplatin loaded L/D-MnO 2 (L/D-MnO 2 @Pt) NPs were successfully constructed based on the high specific surface area of L/D-MnO 2 NPs. L/D-MnO 2 @Pt NPs could be specifically internalized by tumor cells and efficiently deplete the glutathione (GSH) through redox reaction to release Mn2+ and Pt. The released Mn2+ exhibited strong chemodynamic effect through Fenton-like reaction. The depletion of GSH further improved the chemodynamic therapy (CDT) efficiency. The combination of the CDT of Mn2+ with the chemotherapy of Pt considerably enhanced the tumor therapy efficiency. It was particularly noteworthy that L/D-MnO 2 @Pt NPs showed chirality-based different internalization by tumor cells and further led to different tumor cell ablation effects, in which D-MnO 2 @Pt NPs exhibited stronger therapeutic efficiency than L-MnO 2 @Pt NPs. These findings provided deep insights for novel biomedical applications of chirality-based semiconductors NPs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00219797
- Volume :
- 616
- Database :
- Academic Search Index
- Journal :
- Journal of Colloid & Interface Science
- Publication Type :
- Academic Journal
- Accession number :
- 156519289
- Full Text :
- https://doi.org/10.1016/j.jcis.2022.02.060