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Cu microcrystals garnished with copper nanoparticles catalyzed one‐pot facile synthesis of novel 1,2,3‐triazoles via click chemistry as antifungal agents.
- Source :
-
Applied Organometallic Chemistry . May2022, Vol. 36 Issue 5, p1-15. 15p. - Publication Year :
- 2022
-
Abstract
- A remarkable, efficacious, and environmental friendly one‐pot procedure affianced for the synthesis of 1,2,3‐triazoles by 1,3‐dipolar cycloaddition of aromatic azides, terminal alkynes over Cu microcrystals (CuMCs) by click chemistry as subsequent way. The predominance of this method is green synthetic pathway, transient reaction times, facile workup, exceptional yields (87% to 90%) with excellent purity, regioselective single product formation, and eco‐friendliness of the CuMCs catalyst. Docking studies manifested strong binding interactions with enzyme sterol 14‐alpha‐demethylase (PDB ID: 3KHM) with excellent C‐score values. The antifungal screening of synthesized compounds revealed promising activity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02682605
- Volume :
- 36
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Applied Organometallic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 156523030
- Full Text :
- https://doi.org/10.1002/aoc.6664