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Molecular Evolutionary Rate Predicts Intraspecific Genetic Polymorphism and Species-Specific Selection.

Authors :
Wu, Jiaqi
Yonezawa, Takahiro
Kishino, Hirohisa
Source :
Genes. Apr2022, Vol. 13 Issue 4, p708-708. 18p.
Publication Year :
2022

Abstract

It is unknown what determines genetic diversity and how genetic diversity is associated with various biological traits. In this work, we provide insight into these issues. By comparing genetic variation of 14,671 mammalian gene trees with thousands of individual human, chimpanzee, gorilla, mouse, and dog/wolf genomes, we found that intraspecific genetic diversity can be predicted by long-term molecular evolutionary rates rather than de novo mutation rates. This relationship was established during the early stage of mammalian evolution. Moreover, we developed a method to detect fluctuations of species-specific selection on genes based on the deviations of intraspecific genetic diversity predicted from long-term rates. We showed that the evolution of epithelial cells, rather than connective tissue, mainly contributed to morphological evolution of different species. For humans, evolution of the immune system and selective sweeps caused by infectious diseases are the most representative examples of adaptive evolution. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20734425
Volume :
13
Issue :
4
Database :
Academic Search Index
Journal :
Genes
Publication Type :
Academic Journal
Accession number :
156534365
Full Text :
https://doi.org/10.3390/genes13040708