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Development of a synbiotic that protects against ovariectomy-induced trabecular bone loss.
- Source :
-
American Journal of Physiology: Endocrinology & Metabolism . Apr2022, Vol. 322 Issue 4, pE344-E354. 11p. - Publication Year :
- 2022
-
Abstract
- The gut microbiome has the capacity to regulate bone mass. The aim of this study was to develop a nutritional synbiotic dietary assemblage at an optimal dose to maintain bone mass in ovariectomized (Ovx) mice. We performed genomic analyses and in vitro experiments in a large collection of bacterial and fungal strains (>4,000) derived from fresh fruit and vegetables to identify candidates with the synergistic capacity to produce bone-protective short-chain fatty acids (SCFA) and vitamin K2. The candidate SBD111-A, composed of Lactiplantibacillus plantarum, Levilactobacillus brevis, Leuconostoc mesenteroides, Pseudomonas fluorescens, and Pichia kudriavzevii together with prebiotic dietary fibers, produced high levels of SCFA in vitro and protected against Ovx-induced trabecular bone loss in a dose-dependent manner in mice. Metagenomic sequencing revealed that SBD111-A changed the taxonomic composition and enriched specific pathways for synthesis of bone-protective SCFA, vitamin K2, and branched-chain amino acids in the gut microbiome. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANCELLOUS bone
*SYNBIOTICS
*VITAMIN K2
*SHORT-chain fatty acids
*GUT microbiome
Subjects
Details
- Language :
- English
- ISSN :
- 01931849
- Volume :
- 322
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- American Journal of Physiology: Endocrinology & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 156542459
- Full Text :
- https://doi.org/10.1152/ajpendo.00366.2021