虫草素对慢性肾脏病大鼠血管内皮损伤的保护作用及其机制.

To investigate the protective effect of cordycepin on vascular endothelial injury in rats with chronic kidney disease (CKD) and its mechanism. Chronic kidney disease rats (n=48) were randomly equally divided into four groups-model group, cordycepin high-dose group, cordycepin middle-dose group, cordycepin low-dose group. The cordycepin high-dose group, cordycepin middle-dose group, cordycepin low-dose group were given 160 mg/kg, 80 mg/kg, 40 mg/kg cordycepin, and the model group were given the same amount of normal saline, once a day for 2 weeks. The 24 h urine output, blood urea nitrogen (BUN) and serum creatinine (Scr) levels of cordycepin high-dose group, cordycepin middle-dose group and cordycepin low-dose group at 1 week and 2 weeks of treatment were all lower than the model group (P<0.05), and the body weight were higher than the model group (P<0.05). The difference compared among the different dose groups were also statistically significant(P<0.05). The relative expression levels of connective tissue growth factor (CTGF) and vascular endothelial growth factor (VEGF) proteins in the high-dose cordycepin group, the middle- dose cordycepin group, and the low-dose cordycepin group at 2 weeks of treatment were higher than the model group (P<0.05), the glomerular sclerosis index and renal tubular injury score were lower than the model group (P<0.05), and the difference compared among different dose groups were also statistically significant (P<0.05). The application of cordycepin in rats with chronic kidney disease can exert protective effect on vascular endothelial damage, promote the improvement of the renal function of rats, and increase the weight of rats, and it is dose-dependent. [ABSTRACT FROM AUTHOR]