动态超声造影监测高强度聚焦超声治疗腹部 恶性肿瘤疗效的临床价值.

Objective To evaluate the clinical value of dynamic contrast enhanced ultrasound (DCEUS) in monitoring therapeutic effect of high-intensity focused ultrasound (HIFU) in patients with solid abdominal malignant tumors by compare the quantitative ananlysis curve and perfusion parametters. Methods From Sep 2018 to May 2021, patients with histopathologically confirmed advanced abdominal malignant tumors and planned to receive HIFU treatment were prospectively included. Contrast enhanced ultrasound (CEUS) examinations were performed 1 day before and 4 weeks after the initiation of HIFU treatment.CEUS cines in DICOM form were converted into time intensity curves (TICs) using Vuebox software. Various quantitative CEUS parameters were generated after curve fitting, including peak enhancement (PE), rise time (RT), time to peak (TTP), mean transit time (mTT) and area under curve (AUC).Comparisons of sizes, CEUS enhancement patterns, shape of TICs, quantitative CEUS parameters and serum tumor marker levels were conducted before and after HIFU treatment. Results A total of 19 patients were prospectively enrolled (10 women, 9 men；average age, 58.84±10.08 years). While comparing before and after HIFU treatment, no significant difference was observed on mean size of lesions, CEUS features or serum tumor markers.After HIFU treatment, TICs showed decreased enhancement, and AUC decreased either.Among all CEUS quantitative parameters, significant decrease could be found in PE ［(32 920.63±24 822.71) a. u vs. (17 296.11±16 570.41) a. u, P=0.001］and AUC［(624 665.28±593 711.71) a. u vs. (309 148.00±366 938.07) a. u, P=0.002]. Conclusion DCEUS may be a potential imaging method in detecting microvascular change of HIFU in patients with abdominal solid malignant tumor lesions.PE and AUC might be useful DCEUS quantitative parameters. [ABSTRACT FROM AUTHOR]