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Anti-prion activity of cellulose ether is impaired in mice lacking pre T-cell antigen receptor α, T-cell receptor δ, or lytic granule function.
- Source :
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International Immunopharmacology . Jun2022, Vol. 107, pN.PAG-N.PAG. 1p. - Publication Year :
- 2022
-
Abstract
- • Immune system roles in the anti-prion action of cellulose ether (CE) are unknown. • CE effect is impaired by pre T-cell antigen receptor α deficiency or thymectomy. • CE effect is also impaired by TCRδ deficiency or lytic granule dysfunction. • The αβ T-cell lineage, B cells or TLR4 signaling pathway do not affect CE effect. • Interaction between NKT and γδ T cells may be involved in the action of CE. The anti-prion activity of cellulose ether (CE) has been reported in rodents, but the mechanism of action is not well understood. As defects in early T-cell development have been reported in Tga20 mice which show only a slight effect of CE administration, we investigated the involvement of immune functions in the CE action. We confirmed an insertion of the prion protein transgene into the pre T-cell antigen receptor α gene of Tga20 mice, and its impaired expression in the thymus and other tissues. The influence of immune suppression on the CE effect was then examined in high CE-responder mice treated with immunosuppressive agents or neonatal thymectomy. As neonatal thymectomy significantly reduced the CE effect, we compared the influence of various T-cell defects in mice with similar genetic backgrounds. The CE effect was increased or unchanged in mice with defects in the αβ T-cell lineage, whereas it was abolished in T-cell receptor δ deficient mice. Further, when other immune defects were examined, the CE effect was reduced in mice with lysosomal trafficking dysfunction, but was unchanged in mice deficient in B-cell differentiation or toll-like receptor 4 signaling. These findings collectively suggest that the mechanism of CE action may involve γδ T cells and lytic granule function, as well as immune factors like natural killer T cells which are lacking in pre T-cell antigen receptor α deficient mice and neonatally thymectomized mice. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTIGEN receptors
*CYTOTOXIC T cells
*KILLER cells
*T cells
*B cells
*CELLULOSE
Subjects
Details
- Language :
- English
- ISSN :
- 15675769
- Volume :
- 107
- Database :
- Academic Search Index
- Journal :
- International Immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 156673634
- Full Text :
- https://doi.org/10.1016/j.intimp.2022.108672