Tissue residency of memory CD8+ T cells matters in shaping immunogenicity of ovarian cancer.

In this issue of Cancer Cell , Anadon et al. perform a multi-omics analysis of ovarian tumor infiltrating tissue-resident memory T (TRM) cells at the single-cell level that supports a differentiation model from CD103−TCF1+ re-circulating T-cell precursors driven by tumor antigen recognition. CD103+ TRM cells play a dominant anti-tumor role in ovarian cancer. [ABSTRACT FROM AUTHOR]