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Effect of regional versus general anaesthesia on postoperative opioid consumption, clinical outcomes and cognitive function in Chinese patients undergoing metastatic cancer surgery.
- Source :
-
Tropical Journal of Pharmaceutical Research . Apr2022, Vol. 21 Issue 4, p879-886. 8p. - Publication Year :
- 2022
-
Abstract
- Purpose: To compare postoperative opioid consumption, inflammatory biomarkers, cognitive function and safety profile of regional anesthesia (RA) versus general anesthesia (GA) in Chinese patients undergoing metastatic cancer surgery. Method: Chinese patients undergoing metastatic cancer surgery were enrolled and received either RA or GA) in allocation ratio of 1:1. The following efficacy variables were assessed: 1) pain score was measured on VAS scale; 2) post-operative consumption; 3) inflammatory biomarkers; 4) cognitive function; 5) clinical outcomes. Safety was also assessed. Results: Data for a total of 220 patients were analyzed. Compared to GA alone, the combination of RA and GA demonstrated significantly greater reduction in post-operative pain with decreased postoperative opioid consumption. Also, RA/GA combination inhibited inflammatory response when compared to patients who received GA only, indicating that RA + GA improved immune response in patient undergoing surgical intervention. The severity of signs and symptoms of dementia were similar at baseline visit (p > 0.05). Patients of RA/GA group had significantly greater relief in signs and symptoms of dementia/cognitive impairment, when compared to the GA-treated patients (p < 0.05). However, incidence of complications (including adverse events) was comparable for both groups (p > 0.05). Additionally, RA/GA was also associated with shorter length of hospital stay, compared to GA. Conclusion: RA/GA combination demonstrates significantly greater improvement in the level of clinical outcomes, decreases postoperative opioid consumption, and improves cognitive functions when compared to GA in Chinese patients undergoing metastatic cancer surgery. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15965996
- Volume :
- 21
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Tropical Journal of Pharmaceutical Research
- Publication Type :
- Academic Journal
- Accession number :
- 156758936
- Full Text :
- https://doi.org/10.4314/tjpr.v21i4.27