Supramolecularly regulated artificial transmembrane signal transduction for 'ON/OFF'-switchable enzyme catalysis.

An artificial signal transduction model with a supramolecular recognition headgroup, a membrane anchoring group, and a pro-enzyme catalysis endgroup was constructed. The transmembrane translocation of the transducer can be reversibly regulated by competitive host–guest complexations as an input signal to control an enzyme reaction inside the lipid vesicles. [ABSTRACT FROM AUTHOR]