Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death.

Authors :: Lin Liu
Sandow, Jarrod J.
Pedrioli, Deena M. Leslie
Samson, Andre L.
Silke, Natasha
Kratina, Tobias
Ambrose, Rebecca L.
Doerflinger, Marcel
Zhaoqing Hu
Morrish, Emma
Diep Chau
Kueh, Andrew J.
Fitzibbon, Cheree
Pellegrini, Marc
Pearson, Jaclyn S.
Hottiger, Michael O.
Webb, Andrew I.
Lalaoui, Najoua
Silke, John
Source :: Science Advances. 5/11/2022, Vol. 8 Issue 19, p1-15. 34p.
Publication Year :: 2022
Abstract: The article presents a study which explores about the Tankyrase-mediated ADP-ribosylation as a regulator of Tumor necrosis factor (TNF)-induced death. It mentions that TNF, a key component of the innate immune response and suggests that disruption of ADP-ribosylation during an infection can prime a cell to retaliate with an inflammatory cell death.