Back to Search Start Over

Pretreatment Nutrition-Inflammation Biomarkers Correlated with Differential Cytokine Profiles in Taiwanese Patients with Colorectal Cancer.

Authors :
Yu, Yen-Lin
Tseng, Wen-Ko
Fan, Chung-Wei
Chang, Pei-Hung
Kuo, Hsuan-Chih
Pan, Yi-Ping
Yeh, Kun-Yun
Source :
Nutrition & Cancer. 2022, Vol. 74 Issue 5, p1614-1624. 11p. 1 Diagram, 3 Charts, 1 Graph.
Publication Year :
2022

Abstract

Systemic inflammation plays a pivotal role in colorectal cancer (CRC) development. Two hallmarks reflect the severity of inflammation—circulating cytokines and nutrition-inflammation biomarkers (NIBs); however, their interplay has not been fully investigated. In total, 128 CRC patients were included. Ten circulating cytokines (TNF-α, TGF-β, IFN-γ, IL-1β, IL-4, IL-6, IL-10, IL-12, IL-13, and IL-23) and NIBs were analyzed. The relationship between cytokines, NIBs, clinicopathological variables, and overall survival (OS) was assessed using univariate and multivariate analyses. Three NIBs (CRP-to-albumin ratio [CAR]), neutrophil-to-lymphocyte ratio [NLR]), and prognostic nutritional index [PNI]) were associated with OS in univariate analysis; however, CAR was better for OS prediction in multivariate analysis (P = 0.015). None of the serum cytokines analyzed showed a significant association with OS. High CAR (≥0.25) and high IL-10 (≥76.6 pg/mL), high NLR (≥8.2) and high IL-23 (≥51.2 pg/mL), and high PNI (≥42.4) and high IL-1β (≥14.3 pg/mL) values were correlated. CAR, NLR, and PNI were not correlated with each other, whereas circulating cytokines were closely interrelated. High CAR was an independent predictor of poor OS in patients with CRC. Different NIBs have unique cytokine profiles, but show no correlation with each other. There is a close association among the circulating cytokines. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01635581
Volume :
74
Issue :
5
Database :
Academic Search Index
Journal :
Nutrition & Cancer
Publication Type :
Academic Journal
Accession number :
156835411
Full Text :
https://doi.org/10.1080/01635581.2021.1957130