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Evaluation of antioxidant, cytotoxicity, and anti-ovarian cancer properties of the Fe3O4@CS-Starch/Cu bio-nanocomposite.
- Source :
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Inorganic Chemistry Communications . Jun2022, Vol. 140, pN.PAG-N.PAG. 1p. - Publication Year :
- 2022
-
Abstract
- [Display omitted] • Green supported of Cu NPs on Fe 3 O 4 nanoparticles using chitosan-starch composite. • The chitosan-starch composite acted as green reductant and stabilizing agent. • The Fe 3 O 4 @CS-Starch/Cu shown good anti-ovarian cancer activity. • The Fe 3 O 4 @CS-Starch/Cu shown good anti-oxidant activity. In the recent days, conjugated bio-nanomaterials involving magnetic core are interested as promising platform in new generation biological composites. In this regard, we report herein a novel Cu NPs supported chitosan-starch composite functionalized Fe 3 O 4 , a dual core–shell type nanoparticle (Fe 3 O 4 @CS-Starch/Cu). The post-synthetically modified biogenic material was analyzed in details over a number of physicochemical methods like, Transmission Electron Microscope (TEM), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray Diffraction (XRD), energy-dispersive X-ray analysis (EDX), vibrating sample magnetometer (VSM) and inductively coupled plasma (ICP) techniques. In the medicinal part, the anticancer properties of Fe 3 O 4 @CS-Starch/Cu against ovarian cancer cell lines were determined. The free radical for the antioxidant effects was DPPH. The IC 50 were 198 and 155 µg/ml against Fe 3 O 4 @CS-Starch/Cu bio-nanocomposite and BHT. The IC 50 of the Fe 3 O 4 @CS-Starch/Cu bio-nanocomposite were 248, 189, and 281 µg/mL against ovarian cancer (PA-1, SW-626, and SK-OV-3) cell lines. In addition, the current study offer that Fe 3 O 4 @CS-Starch/Cu bio-nanocomposite could be a new potential adjuvant chemopreventive and chemotherapeutic agent against cytotoxic cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IRON oxide nanoparticles
*IRON oxides
*STARCH
*TRANSMISSION electron microscopes
Subjects
Details
- Language :
- English
- ISSN :
- 13877003
- Volume :
- 140
- Database :
- Academic Search Index
- Journal :
- Inorganic Chemistry Communications
- Publication Type :
- Academic Journal
- Accession number :
- 156844546
- Full Text :
- https://doi.org/10.1016/j.inoche.2022.109452