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C−H Hydroxylation of Quinoxalin‐2(1H)‐ones through ipso‐Substitution Using tert‐Butyl Nitrite.
- Source :
-
European Journal of Organic Chemistry . 5/13/2022, Vol. 2022 Issue 18, p1-5. 5p. - Publication Year :
- 2022
-
Abstract
- A convenient one‐pot synthesis of quinoxaline‐2,3‐dione has been achieved by C−H hydroxylation of quinoxalin‐2(1H)‐one using TBN (tert‐butyl nitrite) as a promoter of the reaction in DMSO. First radical‐mediated nitration using TBN at C‐3 of quinoxalin‐2(1H)‐one and followed by hydroxylation with water via ipso‐substitution led to the quinoxaline‐2,3‐dione. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYDROXYLATION
*NITRITES
*NITRATION
*DIMETHYL sulfoxide
Subjects
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2022
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 156868895
- Full Text :
- https://doi.org/10.1002/ejoc.202200425