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Cell Death by Entosis: Triggers, Molecular Mechanisms and Clinical Significance.

Authors :
Kianfar, Mostafa
Balcerak, Anna
Chmielarczyk, Mateusz
Tarnowski, Leszek
Grzybowska, Ewa A.
Source :
International Journal of Molecular Sciences. May2022, Vol. 23 Issue 9, p4985-4985. 12p.
Publication Year :
2022

Abstract

Entosis—a homotypic insertion of one cell into another, resulting in a death of the invading cell—has been described in many reports, but crucial aspects of its molecular mechanisms and clinical significance still remain controversial. While actomyosin contractility of the invading cell is very well established as a driving force in the initial phase, and autophagy induced in the outer cell is determined as the main mechanism of degradation of the inner cell, many details remain unresolved. The multitude of triggering factors and crisscrossing molecular pathways described in entosis regulation make interpretations difficult. The question of the physiological role of entosis also remains unanswered. In this review, we summarize the knowledge of molecular mechanisms and clinical data concerning entosis accumulated so far, highlighting both coherent explanations and controversies. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*CELL death
*ACTOMYOSIN
*AUTOPHAGY

Details

Language :
English
ISSN :
16616596
Volume :
23
Issue :
9
Database :
Academic Search Index
Journal :
International Journal of Molecular Sciences
Publication Type :
Review
Accession number :
156872352
Full Text :
https://doi.org/10.3390/ijms23094985