Back to Search
Start Over
Rapid Generation of Tetrahydropyridines and Tetrahydroquinolines by Dearomative Cyanation/Grignard Addition.
- Source :
-
Chemistry - An Asian Journal . 5/16/2022, Vol. 17 Issue 10, p1-5. 5p. - Publication Year :
- 2022
-
Abstract
- A rapid, practical and scalable method for the reductant and tansition‐metal‐free synthesis of a variety of novel 2,4‐disubstituted tetrahydropyridines and tetrahydroquinolines is disclosed. The method is based upon dearomative functionalization of pyridines or quinolines to generate amino nitrile intermediates as masked iminium ions, which then react rapidly with various Grignard reagents in complete stereocontrol. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IONS
*HETEROCYCLIC compounds
Subjects
Details
- Language :
- English
- ISSN :
- 18614728
- Volume :
- 17
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Chemistry - An Asian Journal
- Publication Type :
- Academic Journal
- Accession number :
- 156900901
- Full Text :
- https://doi.org/10.1002/asia.202200077