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Pre existing memory CD4+ T cells contribute to the primary response in an HIV-1 vaccine trial.
- Source :
-
Journal of Clinical Investigation . Dec2021, Vol. 131 Issue 23, p1-7. 7p. - Publication Year :
- 2021
-
Abstract
- Naive and memory CD4+ T cells reactive with human immunodeficiency virus type 1 (HIV-1) are detectable in unexposed, unimmunized individuals. The contribution of preexisting CD4+ T cells to a primary immune response was investigated in 20 HIV-1–seronegative volunteers vaccinated with an HIV-1 envelope (Env) plasmid DNA prime and recombinant modified vaccinia virus Ankara (MVA) boost in the HVTN 106 vaccine trial (clinicaltrials.gov NCT02296541). Prevaccination naive or memory CD4+ T cell responses directed against peptide epitopes in Env were identified in 14 individuals. After priming with DNA, 40% (8/20) of the elicited responses matched epitopes detected in the corresponding preimmunization memory repertoires, and clonotypes were shared before and after vaccination in 2 representative volunteers. In contrast, there were no shared epitope specificities between the preimmunization memory compartment and responses detected after boosting with recombinant MVA expressing a heterologous Env. Preexisting memory CD4+ T cells therefore shape the early immune response to vaccination with a previously unencountered HIV-1 antigen. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNOLOGIC memory
*VACCINE trials
*VACCINE effectiveness
*VACCINIA
*HIV
Subjects
Details
- Language :
- English
- ISSN :
- 00219738
- Volume :
- 131
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 156902450
- Full Text :
- https://doi.org/10.1172/jci150823