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Two new diterpenoids from the stems of Rhododendron dauricum as GABAA receptor agonists.
- Source :
-
Journal of Asian Natural Products Research . Jun2022, Vol. 24 Issue 6, p542-549. 8p. - Publication Year :
- 2022
-
Abstract
- Two new diterpenoids, dauricumins A (1) and B (2), together with two known aromatic meroterpenoids (3 and 4), were isolated from the petroleum ether soluble fraction of the stems from Rhododendron dauricum through an HPLC-MS-SPE-NMR combination strategy. The absolute configurations of 1 and 2 were elucidated by ECD calculations and [Rh2 (OCOCF3)4]-induced CD spectrum analysis. In a membrane potential FLIPR assay, confluentin (4) showed an agonistic effect on GABAA receptor (EC50 = 20 µM). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 24
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 156916699
- Full Text :
- https://doi.org/10.1080/10286020.2021.2007089