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Pretransplant Serum Fibrinogen Level may be a Predictive Marker on Chronic Graft-Versus-Host Disease (cGVHD) in Patients Having Undergone Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT).
- Source :
-
UHOD: International Journal of Hematology & Oncology / Uluslararasi Hematoloji Onkoloji Dergisi . 2022, Vol. 32 Issue 1, p8-15. 8p. - Publication Year :
- 2022
-
Abstract
- Inflammatory processes play an important role in the pathophysiology of cGVHD. Serum fibrinogen is a proinflammatory protein with a wide range of functions in inflammation. But its role in GVHD is unclear. The aim of this study was to evaluate the predictive impact of pre-transplantation fibrinogen levels on cGVHD in allo-HSCT recipients. We retrospectively analyzed 249 patients with hematologic diseases undergoing allo-HSCT from 10/10 HLA-matched donors. Serum high fibrinogen levels at the time of HSCT (day 0) were significantly associated with cGVHD development in univariate analyses (OR 2.01, p= 0.012) and multivariate analyses (OR 1.003, p= 0.037). There was no significant association between fibrinogen levels and overall survival, disease-free survival and, acute GVHD (p> 0.05). This is the first report demonstrating the association between high fibrinogen levels and increased cGVHD occurrence. Further studies are warranted and may identify the efficacy of fibrinogen as a predictive marker on cGVHD in allo-HSCT recipients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1306133X
- Volume :
- 32
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- UHOD: International Journal of Hematology & Oncology / Uluslararasi Hematoloji Onkoloji Dergisi
- Publication Type :
- Academic Journal
- Accession number :
- 157013569
- Full Text :
- https://doi.org/10.4999/uhod.225936