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Pd2dba3/P(t-Bu)3H.BF4/Cy2NMe Catalyzed Heck Coupling in Synthesis of 3-Alkenyl-1H-Isochromen-1-Ones.
- Source :
-
Polycyclic Aromatic Compounds . 2022, Vol. 42 Issue 4, p1048-1060. 13p. - Publication Year :
- 2022
-
Abstract
- An efficient catalytic system comprising of Pd2dba3/P(t-Bu)3H.BF4/Cy2NMe –for the Heck coupling in the synthesis of 3-alkenyl isochromen-1-ones, 3 has been developed. Air stable alkyl phosphonium salt, [(t-Bu)3Ph]BF4 was found to be vital for the activation of 3- chloroisochromen-1-ones, 1 in regio-selective Heck coupling reactions. The technique has additionally been reached out to typharin, penicilisorin and artemidin analogs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HECK reaction
*PHOSPHONIUM compounds
*ISOCOUMARINS
Subjects
Details
- Language :
- English
- ISSN :
- 10406638
- Volume :
- 42
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Polycyclic Aromatic Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 157070138
- Full Text :
- https://doi.org/10.1080/10406638.2020.1764987