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Cover Feature: Irreversible Inhibition of IspG, a Target for the Development of New Antimicrobials, by a 2‐Vinyl Analogue of its MEcPP Substrate (Chem. Eur. J. 30/2022).
- Source :
-
Chemistry - A European Journal . 5/25/2022, Vol. 28 Issue 30, p1-1. 1p. - Publication Year :
- 2022
-
Abstract
- [4Fe-4S] enzymes, fraudulent substrates, irreversible inhibition, IspG (GcpE), MEP pathway Cover Feature: Irreversible Inhibition of IspG, a Target for the Development of New Antimicrobials, by a 2-Vinyl Analogue of its MEcPP Substrate (Chem. Eur. J. 30/2022) Keywords: [4Fe-4S] enzymes; fraudulent substrates; irreversible inhibition; IspG (GcpE); MEP pathway EN [4Fe-4S] enzymes fraudulent substrates irreversible inhibition IspG (GcpE) MEP pathway 1 1 1 05/27/22 20220525 NES 220525 B The rational design b of a substrate analogue has afforded the first irreversible inhibitor of an IspG enzyme, a target for the development of new drugs to fight antimicrobial resistance. [Extracted from the article]
- Subjects :
- *ANTI-infective agents
*DRUG resistance in microorganisms
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 28
- Issue :
- 30
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 157072939
- Full Text :
- https://doi.org/10.1002/chem.202201234