Cover Feature: Irreversible Inhibition of IspG, a Target for the Development of New Antimicrobials, by a 2‐Vinyl Analogue of its MEcPP Substrate (Chem. Eur. J. 30/2022).

[4Fe-4S] enzymes, fraudulent substrates, irreversible inhibition, IspG (GcpE), MEP pathway Cover Feature: Irreversible Inhibition of IspG, a Target for the Development of New Antimicrobials, by a 2-Vinyl Analogue of its MEcPP Substrate (Chem. Eur. J. 30/2022) Keywords: [4Fe-4S] enzymes; fraudulent substrates; irreversible inhibition; IspG (GcpE); MEP pathway EN [4Fe-4S] enzymes fraudulent substrates irreversible inhibition IspG (GcpE) MEP pathway 1 1 1 05/27/22 20220525 NES 220525 B The rational design b of a substrate analogue has afforded the first irreversible inhibitor of an IspG enzyme, a target for the development of new drugs to fight antimicrobial resistance. [Extracted from the article]