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Potential plants for inflammatory dysfunction in the SARS-CoV-2 infection.
- Source :
-
Inflammopharmacology . Jun2022, Vol. 30 Issue 3, p749-773. 25p. - Publication Year :
- 2022
-
Abstract
- The inflammatory process is a biological response of the organism to remove injurious stimuli and initiate homeostasis. It has been recognized as a key player in the most severe forms of SARS-CoV-2, characterized by significantly increased pro-inflammatory cytokine levels, the so-called "cytokine storm" that appears to play a pivotal role in this disease. Therefore, the aim of this systematic review was to select clinical trials with anti-inflammatory plants and relate the activity of these plants to inflammatory markers of SARS-CoV-2 infection. PRISMA guidelines are followed, and studies of interest are indexed in PubMed and ClinicalTrials.gov databases. As a result, 32 clinical trials encompassing 22 plants were selected. The main anti-inflammatory mechanisms described in the studies are the inhibition of inflammatory cytokines, such as IL-6, TNF-a, IFN-γ, and IL-1; decreased CRP and oxidative marker levels; increased endogenous antioxidant levels; modulation of cardiovascular risk markers. The data found are not directly related to SARS-CoV-2 infection. However, they provide possibilities for new studies as plants have a wide array of phytochemicals, and detecting which ones are responsible for anti-inflammatory effects can provide invaluable contribution to studies aiming to evaluate efficacy in scenarios of SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09254692
- Volume :
- 30
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Inflammopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 157099158
- Full Text :
- https://doi.org/10.1007/s10787-022-00981-5