Asymmetric Henry reaction using a double fluorous-tagged Co–salen complex.

Authors :: Ishihara, Kazuki
Hirota, Soshi
Fujino, Asahi
Ishihara, Kotaro
Shioiri, Takayuki
Matsugi, Masato
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jun2022, Vol. 99, pN.PAG-N.PAG. 1p.
Publication Year :: 2022
Abstract: [Display omitted] A highly stereoselective asymmetric Henry reaction using a double fluorous-tagged Co–salen complex was conducted. The introduction of two fluorous tags into the Co–salen complex was found to be more effective in terms of improving stereoselectivity than the introduction of a strong electron-withdrawing nitro group into the same position of the salen ligand. The observed stereoselectivity was significantly higher than that when using a Jacobsen-type Co–salen complex bearing the same asymmetric source. [ABSTRACT FROM AUTHOR]

Subjects :: *NITROALDOL reactions
*GROUP 15 elements
*STEREOSELECTIVE reactions
*ASYMMETRIC synthesis

Language :: English
ISSN :: 00404039
Volume :: 99
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 157119148
Full Text :: https://doi.org/10.1016/j.tetlet.2022.153833