Pregnancy in cystic fibrosis: Review of the literature and expert recommendations.

• More women with CF desire to have a child and there is an increasing number of annual pregnancies in women with CF. • Pre-pregnancy health can impact maternal and fetal outcomes. Optimizing lung function, body mass index and glucose control are critical. • Highly effective CFTR modulator therapy is improving health in people with CF and potentially increasing fertility. • Discussions surrounding the risks and benefits of continuing medications is critical in women with CF considering pregnancy. • Outcomes in women with CF who experience pregnancy are overall good. Prospective multi-center studies are needed for more granular data. Cystic fibrosis (CF) was historically a disease largely afflicting children. Due to therapeutic advancements, there are now more adults with CF than children. In the past decade, medications including Cystic Fibrosis Transmembrane conductance Regulator (CFTR) modulators became available that treat the underlying cause of CF and are dramatically improving lung function as well as quality and quantity of life for people with CF. As a result, more women with CF are becoming pregnant. We gathered a panel of experts in CF care, family planning, high risk obstetrics, nutrition, genetics and women with CF to review current literature on pregnancies and to provide care recommendations for this unique population. [ABSTRACT FROM AUTHOR]