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Detection of InDel and CNV of SPAG17 gene and their associations with bovine growth traits.
- Source :
-
Animal Biotechnology . Jun2022, Vol. 33 Issue 3, p440-447. 8p. - Publication Year :
- 2022
-
Abstract
- Sperm-associated antigen 17 (SPAG17) gene encodes a central pair protein, which is involved in flagellar motility, male fertility and skeletal growth in ruminants. The insertions/deletions (indels) and copy number variations (CNVs) influence phenotypic traits by altering the sequences and copy numbers of functional genes, respectively. This study identified a novel 8-bp indel of SPAG17 gene in 1520 individuals from eight different cattle breeds, as well as a novel CNV region in 355 animals. The correlation analysis of indel showed that the individuals of ID genotype had superior performance traits such as body height (p = 0.038) and body slanting length (p = 0.041) as compared to other genotypes in Xianan cattle. For the CNV, different copy numbers were closely related to the body height in Qinchuan (p = 0.045) and body weight in Xianan (p = 0.036) breeds. Importantly, significant difference was observed between the 8-bp indel and the copy number loss in Xianan breed (p < 0.01). These findings indicated that the variations within the bovine SPAG17 gene can be considered as an effective DNA molecular marker for beef cattle breeding. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10495398
- Volume :
- 33
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Animal Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 157228152
- Full Text :
- https://doi.org/10.1080/10495398.2020.1803342