A Novel Kindred with MyD88 Deficiency.

The patient was in good clinical condition and did not experience recurrent infections after the start of Ig replacement therapy and antibiotic prophylaxis with amoxicillin until the age of 5 years, when he was admitted to a hospital with COVID-19 pneumonia requiring oxygen therapy for 4 days. Invasive infections with viruses, mycobacteria, parasites, and fungi have not been described in human MyD88 deficiency, although one patient had Bacillus Calmette-Guérin (BCG) adenitis after vaccination with BCG [[2], [5]]. We here present a patient carrying a homozygous deleterious mutation in I MYD88 i , who experienced viral infections and recurrent mucocutaneous candidiasis in addition to the classical invasive and superficial pyogenic infections. [Extracted from the article]