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Gut microbiota and aging.
- Source :
-
Critical Reviews in Food Science & Nutrition . 2022, Vol. 62 Issue 13, p3509-3534. 26p. - Publication Year :
- 2022
-
Abstract
- Aging is characterized by the functional decline of tissues and organs and increased risk of aging-associated disorders, which pose major societal challenges and are a public health priority. Despite extensive human genetics studies, limited progress has been made linking genetics with aging. There is a growing realization that the altered assembly, structure and dynamics of the gut microbiota actively participate in the aging process. Age-related microbial dysbiosis is involved in reshaping immune responses during aging, which manifest as immunosenescence (insufficiency) and inflammaging (over-reaction) that accompany many age-associated enteric and extraenteric diseases. The gut microbiota can be regulated, suggesting a potential target for aging interventions. This review summarizes recent findings on the physiological succession of gut microbiota across the life-cycle, the roles and mechanisms of gut microbiota in healthy aging, alterations of gut microbiota and aging-associated diseases, and the gut microbiota-targeted anti-aging strategies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10408398
- Volume :
- 62
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Critical Reviews in Food Science & Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 157382746
- Full Text :
- https://doi.org/10.1080/10408398.2020.1867054