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Roles for macrophage-polarizing interleukins in cancer immunity and immunotherapy.
- Source :
-
Cellular Oncology (2211-3428) . Jun2022, Vol. 45 Issue 3, p333-353. 21p. - Publication Year :
- 2022
-
Abstract
- Macrophages are the most abundant and one of the most critical cells of tumor immunity. They provide a bridge between innate and adaptive immunity through releasing cytokines into the tumor microenvironment (TME). A number of interleukin (IL) cytokine family members is involved in shaping the final phenotype of macrophages toward either a classically-activated pro-inflammatory M1 state with anti-tumor activity or an alternatively-activated anti-inflammatory M2 state with pro-tumor activity. Shaping TME macrophages toward the M1 phenotype or recovering this phenotypic state may offer a promising therapeutic approach in patients with cancer. Here, we focus on the impact of macrophage-polarizing ILs on immune cells and IL-mediated cellular cross-interactions within the TME. The key aim of this review is to define therapeutic schedules for addressing ILs in cancer immunotherapy based on their multi-directional impacts in such a milieu. Gathering more knowledge on this area is also important for defining adverse effects related to cytokine therapy and addressing them for reinforcing the efficacy of immunotherapy against cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNITY
*INTERLEUKINS
*NATURAL immunity
*THERAPEUTICS
*IMMUNOTHERAPY
*MACROPHAGES
Subjects
Details
- Language :
- English
- ISSN :
- 22113428
- Volume :
- 45
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Cellular Oncology (2211-3428)
- Publication Type :
- Academic Journal
- Accession number :
- 157412818
- Full Text :
- https://doi.org/10.1007/s13402-022-00667-8