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Reproductive factors and gall-bladder cancer, and the effect of common genetic variants on these associations: a case-control study in India.
- Source :
-
International Journal of Epidemiology . Jun2022, Vol. 51 Issue 3, p789-798. 10p. - Publication Year :
- 2022
-
Abstract
- <bold>Background: </bold>In India, as elsewhere, the incidence of gall-bladder cancer (GBC) is substantially higher in women than in men. Yet, the relevance of reproductive factors to GBC remains poorly understood.<bold>Methods: </bold>We used logistic regression adjusted for age, education and area to examine associations between reproductive factors and GBC risk, using 790 cases of histologically confirmed GBC and group-matched 1726 visitor controls. We tested the interaction of these associations by genetic variants known to increase the risk of GBC.<bold>Results: </bold>Parity was strongly positively associated with GBC risk: each additional pregnancy was associated with an ∼25% higher risk {odds ratio [OR] 1.26 [95% confidence interval (95% CI) 1.17-1.37]}. After controlling for parity, GBC risk was weakly positively associated with later age of menarche [postmenopausal women, OR 1.11 (95% CI 1.00-1.22) per year], earlier menopause [OR 1.03 (95% CI 1.00-1.06) per year] and shorter reproductive lifespan [OR 1.04 (95% CI 1.01-1.07) per year], but there was little evidence of an association with breastfeeding duration or years since last pregnancy. Risk alleles of single-nucleotide polymorphisms in the ABCB4 and ABCB1 genetic regions had a multiplicative effect on the association with parity, but did not interact with other reproductive factors.<bold>Conclusions: </bold>We observed higher GBC risk with higher parity and shorter reproductive lifespan, suggesting an important role for reproductive and hormonal factors. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03005771
- Volume :
- 51
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- International Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 157435395
- Full Text :
- https://doi.org/10.1093/ije/dyab197