Numerical investigation on losses and heat-transfer characteristics of Magnetic-heat therapy in deep biological tissue based on magnetothermal gel with medium frequency vortex.

• A human thoracic tissue lung tumor model for calculating magnetothermal effects is established. • The magnetothermal generation model is designed and applied. • The accuracy of the numerical model is verified by the experimental and computational comparison of the magnetothermal gel for tumor treatment. • The temperature distribution of the magnetothermal gel is investigated by infrared measurements and model calculations. • The effects of different influencing factors on the temperature of the magnetothermal gel are discussed to evaluate the effect of tumor treatment. This paper proposes a medium frequency magnetothermal treatment method, which can be used for a certain depth of thermal hyperthermia of tumor tissue in vivo. Firstly, a magnetothermal treatment program using a vortex coil is designed with a medium frequency alternating magnetic field, which can better realize the external implementation. Next, the electromagnetic field of the vortex coil is simulated by finite element method, and the electromagnetic field distribution characteristics of the system are obtained for treatment reference. Then, the preparation and composition design of the gel suitable for the magnetothermal effect are studied, and the temperature rise experiment is carried out to verify the reliability of the temperature rise of the magnetothermal gel. Finally, the human thoracic cavity tissue model is established to calculate the magnetothermal effect of the gel on the lung tumor tissue. And the thermal effect and temperature distribution of different physical parameters on the tissue are obtained. The results show that the magnetothermal therapy can penetrate non-magnetic barriers and effectively generate a temperature rise on the magnetothermal gel injected into the body, so that the tumor tissue in a certain space is inhibited by the temperature rise in a short time. Therefore, the research results in this article provide important theoretical and clinical value for non-invasive hyperthermia of tumors in vivo. [ABSTRACT FROM AUTHOR]