阿霉素注射剂量对肾病综合征大鼠脂蛋白脂酶 和卵磷脂胆固醇酰基转移酶水平的影响.

To investigate the effects of doxorubicin injection on the levels of lipoprotein lipase and leci-thin cholesterol acyltransferase (LCAT) in rats with nehpmtic syndrome (NS). Sixty-four SD rats were randomly divided into four groups, namely: matched group, low-dose adriamycin group, medium-dose adriamycin group and high-dose adriamycin group. The four groups of rats were injected with adriamycin through the tail vein at one time at 0 mg/kg, 2 mg/kg, 4 mg/kg, 8 mg/kg, the changes in rat kidney lipoprotein lipase and LCAT levels were detected at different time points after modeling. The body weight, daily feed intake, blood creatinine and urea nitrogen of the low-dose doxorubicin group, medium-dose doxorubicin group and high-dose doxorubicin group were lower than those of the matched group (P<0.05) at 7 d, 14 d, 21 d after modeling, the 24 h urine protein were higher than that of the matched group (P<0.05), and there were adose-dependence, the difference compared among the three groups were statistically significant (P<0.05). The relative expression levels of renal lipoprotein lipase and lecithin cholesterol acylase in the low-dose doxorubicin group, medium-dose doxorubicin group, and high-dose doxorubicin group were lower than those in the matched group at 21 d and 28 d after modeling (P<0.05). and there were dose-dependence, the difference compared among the three groups were statistically significant (P<0.05). A small dose of doxorubicin can inhibit the expression of lipoprotein lipase and LCAT in rat kidneys, and can quickly and effectively establish rat model of nephrotic syndrome with good simulation effect. [ABSTRACT FROM AUTHOR]